ActivatingHRASMutation in Agminated Spitz Nevi Arising in a Nevus Spilus

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[Agminated Spitz nevi on a hyperpigmented macule].

We present the case of a 2-year-old boy with multiple Spitz nevi clustered on a hyperpigmented macule that obeyed a quadrant distribution. Multiple Spitz nevi are rare and can be disseminated or clustered. A third of the cases of agminated lesions appear on hyperpigmented macules.

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Nevus spilus is a melanocytic cutaneous lesion consisting of a light brown background macule with numerous superimposed darker maculopapular speckles. Melanoma arising from a nevus spilus is rare, with less than 40 cases reported to date. The absolute risk for malignant transformation is not well defined, lacking a standardized management approach. We report a new case of melanoma arising from ...

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Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculosus.

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Multiple Agminated Acquired Melanocytic Nevi

Vol. 25, No. 2, 2013 251 Received June 8, 2012, Revised July 13, 2012, Accepted for publication August 10, 2012 Corresponding author: You Chan Kim, Department of Dermatology, Ajou University School of Medicine, 164 WorldCup-ro, Yeongtong-gu, Suwon 443-721, Korea. Tel: 82-31-219-5190, Fax: 82-31-219-5189, E-mail: [email protected] This is an Open Access article distributed under the terms of th...

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ژورنال

عنوان ژورنال: JAMA Dermatology

سال: 2013

ISSN: 2168-6068

DOI: 10.1001/jamadermatol.2013.4745